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A 6 page paper proposing a research project designed to discover some of the mechanisms of pathogenesis of rheumatoid arthritis resulting from the influence of rheumatoid factor. Early research discovered elevated levels of immunoglobulin G (IgG) in patients seropositive for rheumatoid arthritis, but it was not known if there was any relation between the presence of these IgG substances and the presentation of rheumatoid arthritis. It has since been established that IgG, as well as other dimers of Ig have some primary role in either the development or the advance of the disease, and it is believed that the role has at least some causative effect. The purpose of this proposed research is to attempt to discover what that effect might be. Bibliography lists 10 sources.
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